Abstract
The effect of paclitaxel on the in vitro radiation sensitivity of the uterine cervical cancer cell line SKG IIIa was studied in vitro. Three-hour incubation of cells in low-concentration paclitaxel (3 nmol/L), which has little suppressive activity on cell growth, for 3 hours 48 hours before irradiation at 1.5 Gy, produced a cell growth-suppressing effect that was statistically significant compared with that produced by 1.5 Gy irradiation alone. Cell cycle analysis demonstrated a temporary increase in the number of S phase cells after paclitaxel administration, but no G 2 or M phase blocking. Although the mechanism by which paclitaxel sensitizes these cells to radiation in vitro is not known, results suggest that paclitaxel may be clinically useful as a radiosensitizer in the treatment of uterine cervical cancer and should be further evaluated.
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