Abstract
Tetraethylammonium salts (bromide and chloride) are the latest drugs to find application in treatment of peripheral vascular diseases. They act on the ganglions of the autonomic nervous system by blocking the impulses peripheral to the ganglions. 1 The most important clinical application of these drugs is in conditions such as thrombophlebitis, peripheral arteriosclerosis obliterans, Raynaud's disease, thromboangiitis obliterans (Buerger's disease) and various other peripheral vascular disorders, in which the tone of blood vessels should be decreased. 2 We have found no report of cutaneous sensitivity to this drug, and we feel that the following case may be of significance. REPORT OF CASE B. M., a 46 year old white woman, had had trouble with varicose veins for seven years. In December 1946 a varicose ulcer developed on the pretibial area of the left leg, and the patient was given 200 mg. of tetraethylammonium chloride intravenously on March 8 and on March 22,
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