Abstract

Five cases of sensitivity to Merthiolate are reported in which intradermal tests with antigens containing Merthiolate as a preservative caused consistently delayed tuberculin-type reactions. The allergic nature of the reactions was proved by positive patch and intradermal tests with Merthiolate. Histologic examination showed an epidermal type reaction to a patch test in one case, and dermal reactions in 2 cases. The intradermal tests showed mainly a dermal infiltrate that often followed sweat ducts and encroached upon sweat coils. Delayed reactions to intradermal tests due to Merthiolate-containing diluting fluid may become a cause of misleading false positive reactions to intradermal tests with so-called simple chemicals such as nickel, dichromate, and neomycin.

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