Abstract
IN 1946 Selye described cold as an alarming stimulus capable of producing all of the systemic effects characterizing the general adaptation syndrome. He had reported changes in carbohydrate metabolism in rats exposed to cold: a marked hyperglycemia-immediately following initial exposure, hypoglycemia on the second day of cold, and hyperglycemia again beginning on the third day and lasting two weeks (stage of resistance). Many alarming stimuli including cold cause increased adrenocortical activity characterized by enlargement of the gland and reduction of its content in ascorbic acid and cholesterol (Selye, 1937; Long, 1947; and Sayers and Sayers, 1948). Masson (1941) found that the hypoglycemia-producing effect of insulin (that is, insulin sensitivity) is increased considerably in the stage of resistance during chronic exposure to a cold environment. More recently Cheng and Sayers (1949) produced hypersensitivity to insulin by administering desoxycorticosterone acetate to adrenal-demedullated rats. In vie...
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