Sensitivity test-guided area chemotherapy for unresectable primary liver cancer

Abstract

Objective To evaluate the effectiveness of sensitivity test-guided area-perfusion chemotherapy for unresectable primaryliver cancer.Methods 120 cases of human liver cancer were divided into two groups at random:experimental group and control group.Guided by the results of drug sensitivity test,3 drugs were chosen and transfused from the liver artery and portal vein pump in the experimental group.The 60 patients in the control group were subjected to transarterial chemoembolization(TACE).The tumor size,levels of alpha fetal protein (AFP),two-step operation rate,survival rate,and complications were compared between two groups.Results The tumor size measured by CT or MRI was ruduced in 28 (47.6％) cases,or stable in 14 (23.3％) cases in experimental group after six courses of chemotherapy,and 17 (28.5％) cases and7 (11.5％) cases in the control group (P＜0.05).The AFP level was declined in 51 cases of experimental group,while in 30 cases of control group (P ＜0.05).In experimental group,the median follow-up time was 21 months,the progression-free survival(PFS) and overall survival (OS) ratio at 6th,12th,and 18th month was 78％,70％,65％ and 86％,72％,and 65％ respectively,which were superior to those in control group (P ＜ 0.05).The incidence of complications in experimental group was lower than in control group (P ＜ O.01).Conclusion The artery and portal vein pump transfusion chemotherapy guided by drug Sensitivity test-guided area-perfusion chemotherapy for unresectable primary liver cancer can prelong PFS and OS,and reduce the incidence of complication. Key words: Primary liver carcinoma; Drug sensitive test; Local chemotherapy