Abstract
Background MNSI is widely used for evaluation of distal symmetric peripheral polyneuropathy (PPN) in individuals with diabetes. In the DCCT/EDIC study, the MNSI was validated for screening of signs and symptoms of PPN, presenting, for a cutoff of ≥2.5, sensitivity of 61%, specificity of 79%, positive predictive value (PPV) of 55% and negative (NPV) of 83%, when compared to neurological examination in combination with nerve conduction studies as gold standard. Objective To evaluate the sensitivity, specificity, PPV, NPV and accuracy of Neuropathy Diabetes Score (NDS) (≥3.0) compared to MNSI score, used as the gold standard.
Highlights
Michigan neuropathy screening instrument (MNSI) is widely used for evaluation of distal symmetric peripheral polyneuropathy (PPN) in individuals with diabetes
In the DCCT/EDIC study, the MNSI was validated for screening of signs and symptoms of PPN, presenting, for a cutoff of ≥2.5, sensitivity of 61%, specificity of 79%, positive predictive value (PPV) of 55% and negative (NPV) of 83%, when compared to neurological examination in combination with nerve conduction studies as gold standard
Compared to MNSI, which evaluates the PPN through the appearance of the feet, presence of ulcers, vibratory sensitivity, monofilament and Achilles reflex, neuropathy diabetes score (NDS) had a sensitivity of 50%, specificity of 93%, PPV of 78%, NPV of 79% and accuracy of 79%, according to Figure 1
Summary
MNSI is widely used for evaluation of distal symmetric peripheral polyneuropathy (PPN) in individuals with diabetes. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of neuropathy diabetes score (NDS) compared with the Michigan neuropathy screening instrument (MNSI) Otto Henrique Nienov*, Lisiane Stefani Dias, Maria Cândida Ribeiro Parisi, Helena Schmid
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