Abstract
Iodine-125 seeds selectively inhibited thyroid compared with parathyroid function. Stimulation of thyroid tissue by TSH and suppression of thyroid tissue by thyroxine did not alter the sensitivity of thyroid tissue to radiation, since serum TSH concentrations were not different in the thyroxine-suppressed, control, or TSH-stimulated animals 9 weeks after discontinuing the radiation. TSH stimulation by the low iodine diet and TSH suppression by exogenous thyroxine did alter the function of the parafollicular C cells of the thyroid, since serum calcitonin concentrations were increased in the former and decreased in the latter. Serum calcium concentrations were also increased in the rats receiving the low iodine diet, but the reason for this increase is not known.
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