Abstract

The effects of raw soya bean in the diet were investigated in the guinea-pig. Weanling guinea-pigs fed raw soya bean for 30 days suffered a high mortality rate. The excised pancreases from the test animals were significantly larger than those from control animals fed a casein diet, but the enlargement was not as marked as that reported for rats and chicks fed similar dietary regimens. Pancreatic trypsinogen, chymotrypsinogen and amylase were all increased by soya feeding in the young guinea-pig. Adult guinea-pigs fed the same soya-bean diet suffered no deaths and showed no pancreatic enlargement compared with controls. Pancreatic trypsinogen and amylase activities were higher than those of control animals but chymotrypsinogen was not changed. The response of the guinea-pig to dietary raw soya bean is similar to that previously observed in other rodents.

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