Abstract
Dose responses were compared of cultured fetal Syrian golden hamster lung cells (FSHL) to the toxic and transforming effects of benzo[ a]pyrene (B[ a]P), benzo[ b]fluoranthene (B[ b]F), benz[ a]anthracene (B[ a]a) indeno[1,2,3- c,d]pyrene (I[ c,d]P), benzo[ k]fluoranthene (B[ k]F) and benzo[ e]pyrene (B[ e]P). Effort was first given to standardising the techniques for evaluating B[ e]P dose-responses. These polycyclic aromatic hydrocarbons (PAH) were then tested at concentrations of up to 1 μg/ml, and only B[ a]P showed clear cytotoxicity. The transforming effects of B[ b]F, B[ a]A and I[ c,d]P at 1 μg/ml appeared comparable to those of B[ a]P at 0.05 μg/ml.
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