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Abstract
We have attempted to define the structural target components for the two cytotoxic mechanisms in rejecting rat heart allograft: antibody-independent (direct) and antibody-dependent (ADCC) cellular cytotoxicity. Immune spleen cells and alloantibody were obtained at 1 and 2 weeks after heart allotransplantation, respectively. The cytotoxicity of immune spleen cells, with and without alloantibody, was tested against endothelial- and myocardial-enriched heart cell populations. We found endothelial cells to be sensitive to direct cellular cytotoxicity, most likely mediated by T lymphocytes, while myocardial cells were sensitive to ADCC. Both reactions were shown to be immunologically specific.
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