Abstract
Comparison of the intrinsic thermosensitivity of malignant and normal homologous cells are important in evaluating the therapeutic role of hyperthermia in cancer. However, such comparisons had problems with establishing the origin of cells grown in culture. Using monoclonal antibodies we have shown that human kidney cancer lines, Caki-1 and Caki-2, and a normal human renal epithelium line, NHK-4, originated from proximal convoluted tubular epithelium. The observed order of thermosensitivity was Caki-2 > Caki-1 > NHK-4.
Published Version
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