Abstract
ACUTE infectious non-bacterial gastroenteritis is a common disease in which recovery usually occurs within 24–48 h of the onset of diarrhoea and vomiting1,2. This short duration suggests that a mechanism of rapid onset, such as interferon, may play a significant role in recovery. The role of interferon in recovery from acute enteric viral infections of man is, however, unknown. Indeed, little is known about the ability of the human intestine to either produce or respond to interferon. We have therefore investigated the role of interferon in viral infections of the human gut. We found that human foetal intestine is quite responsive to the antiviral properties of exogenous interferon, and when so treated exhibits a marked inhibition of the replication of an enteric virus, echovirus type 11.
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