Abstract
The effect of the antifolic drug pyrimethamine (2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine) on cleavage of CBA mouse embryos was studied. Pyrimethamine does not affect the development of early mouse embryos in utero but considerably inhibits cleavage of embryos explanted into medium containing the drug. The sensitivity of mouse and rat embryos to pyrimethamine is compared and it is concluded that there are no interspecific differences in their response to the teratogen at the level of the embryonic cells themselves.
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