Abstract
THE LOCAL use of the sulfonamide compounds in treating acute infections of the nose and throat has received much attention in the last three or four years. The soluble sodium salts of the sulfonamide compounds, especially sodium sulfathiazole, had the earliest<sup>1</sup>and formerly the most frequent use. The principal objection to the soluble sodium salts is their high alkalinity (<i>p</i>H10 to 11), whereas the<i>p</i>Hrange of normal mucous membrane in situ in man is from 5.5 to 6.5 (Fabricant<sup>2</sup>). The 2.5 per cent solution of sodium sulfathiazole in a 0.125 per cent solution of the vasoconstrictor<i>dl</i>-desoxyephedrine hydrochloride is still more alkaline (<i>p</i>H8.6 to 9.2) than the normal nasal mucosa. Callomon<sup>3</sup>observed that this solution produced inflammation and partial caustic effects and that a 2 per cent solution of "diasone" (the disodium formaldehyde sulfoxylate derivative of diaminodiphenylsulfone) with acid properties (pu below 5) caused greater damage to
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