Abstract
This work presents a highly sensitive silver (Ag) based Surface Plasmon Resonance (SPR) sensor with graphene-coated over Silicon nitride (Si3N4) for sensing of Deoxyribonucleic acid (DNA) hybridization. The design consists of five layers namely Ag, Si3N4, graphene, and sensing medium along with BK7 glass prism that couple light at the metal–dielectric interface. The performance of the present structure has been evaluated using the angular interrogation method. The present investigation reveals the difference in complementary DNA strands and mismatched DNA strands as well as single-nucleotide polymorphisms (SNP) event by examining the variation of resonance angle in the reflectivity spectrum. The performance of the present structure is compared with the contemporary structures and found better than existing sensors. Therefore, the proposed structure is suitable in the biochemical field for the detection of biomolecules interactions.
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