Abstract

A high sensitive electrochemical sensor was designed for the real time detection of dopamine (DA) and uric acid (UA) by using the Nanocomposite (NC) of reduced graphene oxide nano-octahedral shaped Mn3O4 modified Glassy Carbon Electrode (rGO/Mn3O4/GCE). The effect of Mn3O4 on the electrochemical and physical properties of rGO/Mn3O4 NC by Mn3O4 contents was analyzed by varying the molar ratio of Mn precursor (1, 5 and 10 mM denoted as GM1:1, GM1:5 and GM1:10 respectively). Due to the unique morphology and physical properties originated from Mn3O4, GM1:10/GCE revealed enhanced electrochemical response in terms of large peak potential separation, high selectivity and sensitivity. The GM1:10/GCE displayed a distinct SWV response to DA and UA for 1–600 μM at lowest detection limit of 1.42 μM and 0.76 μM. Additionally, anti-interference property of the designed sensor against electroactive molecules is found to be excellent stability and good reproducibility. Finally, it was make use for the detection of DA and UA in the pharmaceutical compound and physiological residue.

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