Sensitivity and specificity of cerebrospinal fluid glucose measurement by an amperometric glucometer.

Abstract

Objectives:To provide more data regarding the role of an amperometric glucometer in diagnosing meningitis.Methods:This is a prospective study conducted at the Pediatric and Neonatology Department, Qatif Central Hospital, Qatif, Saudi Arabia between March 2017 and September 2018. We measured glucose concentrations in cerebrospinal fluid (CSF) and blood using a central laboratory and amperometric glucometer (AG). We compared CSF/blood glucose ratios obtained in a central laboratory from clinical bedside examination with a glucometer, and calculated the sensitivity and specificity for detecting cases of meningitis.Results:A total of 101 patients with clinical suspicion of meningitis were recruited for CSF sampling. Of 101 CSF samples, 61 (60%) were suggestive of meningitis. Of 101 samples, 47 had hypoglycorrhachia identified by a standard laboratory, and 17% of them were also detected by AG. The correlation between CSF/blood glucose by AG and laboratory ratios was substantial (r=0.894, p<0.01, 95% CI: 0.805-0.983). The AG sensitivity was 100% and specificity was 55% in pediatric cases, while in neonates the sensitivity was 86% and the specificity was 26%.Conclusion:Amperometric glucometers can be used to detect hypoglycorrhachia accurately. This point-of-care testing tool is easily accessible and can be used by health care providers for cases suspected of meningitis.