Abstract
A sensitive analytical procedure has been developed for the determination of ticlopidine using a multi-walled carbon nanotubes paste electrode (MWCNTsPE) . Direct oxidation of analyte was observed by cyclic voltammetry as evidenced by the presence of well-shaped irreversible peak at 1.05 V vs Ag/AgCl (3.0 mol L –1 KCl) in Britton-Robinson buffer solution (pH 5.0). The use of this electrode has been found to influence the electrochemical determination by presenting a higher intensity of oxidation current for ticlopidine and also a lower detection limit. Using differential pulse voltammetric modality, the obtained analytical curve was linear for ticlopidine concentration ranging from 0.75 to 20 µmol L –1 , with detection limit of 0.10 µmol L –1 . The proposed method was successfully used to determination of ticlopidine in pharmaceuticals, with satisfying results . In order to indicate that the method is of potential application in biological fluids adequate recovery results were obtained for the determination of ticlopidine in synthetic urine sample. DOI: http://dx.doi.org/10.17807/orbital.v8i3.831
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