Sensitive electrochemical nonenzymatic glucose sensing based on anodized CuO nanowires on three-dimensional porous copper foam.

Zhenzhen Li,Yan Chen,Zhonghai Zhang,Yanmei Xin

doi:10.1038/srep16115

Zhenzhen Li, Yan Chen + Show 2 more

Open Access

https://doi.org/10.1038/srep16115

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Journal: Scientific reports	Publication Date: Nov 2, 2015
Citations: 115	License type: CC BY 4.0

Affiliation: East China Normal University

Abstract

In this work, we proposed to utilize three-dimensional porous copper foam (CF) as conductive substrate and precursor of in-situ growth CuO nanowires (NWs) for fabricating electrochemical nonenzymatic glucose sensors. The CF supplied high surface area due to its unique three-dimensional porous foam structure, and thus resulted in high sensitivity for glucose detection. The CuO NWs/CF based nonenzymatic sensors presented reliable selectivity, good repeatability, reproducibility, and stability. In addition, the CuO NWs/CF based nonenzymatic sensors have been employed for practical applications, and the glucose concentration in human serum was measured to be 4.96 ± 0.06 mM, agreed well with the value measured from the commercial available glucose sensor in hospital, and the glucose concentration in saliva was also estimated to be 0.91 ± 0.04 mM, which indicated that the CuO NWs/CF owned the possibility for noninvasive glucose detection. The rational design of CuO NWs/CF provided an efficient strategy for fabricating of electrochemical nonenzymatic biosensors.

Highlights

In this work, we proposed to utilize three-dimensional porous copper foam (CF) as conductive substrate and precursor of in-situ growth CuO nanowires (NWs) for fabricating electrochemical nonenzymatic glucose sensors
As a proof of concept, the cupric oxide nanowires (CuO NWs)/CF was utilized for fabricating electrochemical nonenzymatic glucose sensor, and realized a sensitive glucose detecting in wide linear range with high stability, good reproducibility, and reliable selectivity
From the high resolution transmission electron microscopy (HRTEM) image, as shown in Fig. 2e and Supplementary Fig. S3, the distance between two neighboring lattice fringes of CuO NWs was measured as 0.27 nm, which agreed well with the [110] lattice fringe of the monoclinic CuO31

Summary

Introduction

We proposed to utilize three-dimensional porous copper foam (CF) as conductive substrate and precursor of in-situ growth CuO nanowires (NWs) for fabricating electrochemical nonenzymatic glucose sensors. For successfully fabricating electrochemical nonenzymatic glucose sensor, the electrocatalyst should satisfy these requirements: (1) high electrocatalytic activity; (2) large surface area; (3) effective electron transfer from electrocatalysts to conductive substrate; (4) good selectivity; (5) high stability; and (6) good reproducibility[17,18].

Results

Conclusion