Abstract
An electrochemical HPLC method for the simultaneous determination of haloperidol and reduced haloperidol in plasma is presented. Chlorohaloperidol serves as the internal standard. A cyanopropyl bond elut column was used for sample preparation. The eluate was evaporated and reconstituted with mobile phase and injected onto a nitrile bonded column. The chromatographic system consisted of an ESA Coulochem detector operated in the screen mode. Intra- and interassay coefficients of variation for both compounds were <7%, with a sensitivity limit of 20pg on the column. A plasma level–time profile is presented to illustrate the sensitivity and applicability of this assay in small animal and human pharmacokinetic studies.
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