Abstract
In the present work, a new Graphene-TiO 2 (GR-TiO 2 ) modified glassy carbon electrode (GCE) is suggested for sensitive electrochemical determination of metronidazole (MTZ). Electrochemical studies revealed that GR-TiO 2 nanoparticles increased the efficiency of electron transfer kinetics by increasing the available surface area of the electrode and charge mobility between MTZ and GR-TiO 2 modified electrode. Compared to bare GCE, the modified electrode greatly enhanced the reduction signal of MTZ. The electrochemical behaviour of the modified electrode and the electrochemical reduction of MTZ were investigated with electrochemical impedance spectroscopy, cyclic voltammetry and differential pulse voltammetry techniques. The charge transfer coefficient (α) was calculated to be 0.694. Under optimized conditions, the linear concentration range and detection limit of MTZ were 5.0×10 -7 to 2.5×10 -5 M -1 and 5.4×10 -8 (S/N = 3), respectively. Finally, this sensing method was successfully applied for the determination of MTZ in human blood serum and urine samples.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
