Abstract
Tissue implantation and the measurement of inflammation by the dye extravasation technique are sensitive and rapid methods for screening plastics for toxicity. The subcutaneous and the intramuscular implantation of polyvinyl chloride plastics containing organo-tin stabilizers produces severe local tissu reaction. The degree of extravasation of trypan blue at the site of the injection of a suitable plastic extract is also an indication of compatibility with animal tissues. Mineral oil was found to be a suitable, nonirritating agent for extracting the plastic. The same techniques are suitable for screening raw materials before incorporation into the plastic formulation. Tin stabilizers, such as dibutyltin dilaurate, caused irritation in dilutions as great as 1:10,000.
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