Abstract

Patients with bullous pemphigoid (BP) have circulating autoantibodies directed against two proteins involved in the anchoring of keratinocytes to the extracellular matrix, BP230 and BP180. BP230 is an intracellular protein associated with the hemidesmosomal plaque. BP180 is a transmembrane glycoprotein: One end sits within the cytoplasm of the basal keratinocyte (intracellular) and the other …

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