Abstract
A novel fluorescent probe based on sulfur quantum dots (SQDs) was fabricated for sensitive and selective detection of tetracycline (TC) in milk samples. The blue emitting SQDs were synthesized via a top–down method with assistance of H2O2. The synthesized SQDs showed excellent monodispersity, water solubility and fluorescence stability, with a quantum yield (QY) of 6.30%. Furthermore, the blue fluorescence of the obtained SQDs could be effectively quenched in the presence of TC through the static quenching effect (SQE) and inner filter effect (IFE) between TC and SQDs. Under the optimum conditions, a rapid detection of TC could be accomplished within 1 min and a wide linear range could be obtained from 0.1 to 50.0 μM with a limit of detection (LOD) of 28.0 nM at a signal-to-noise ratio of 3. Finally, the SQD-based fluorescent probe was successfully applied for TC determination in milk samples with satisfactory recovery and good relative standard deviation (RSD). These results indicate that the SQD-based fluorescent probe shows great potential in practical analysis of TC in real samples with high rapidity, selectivity, and sensitivity.
Highlights
Optical probes based on luminescent nanomaterials have drawn considerable attention due to their rapidity, sensitivity, low cost and accuracy for screening of contaminants.[1,2,3] In particular, many uorescent nanomaterials have been applied for fabrication of uorescent probes
The SQD-based fluorescent probe was successfully applied for TC determination in milk samples with satisfactory recovery and good relative standard deviation (RSD)
These results indicate that the SQD-based fluorescent probe shows great potential in practical analysis of TC in real samples with high rapidity, selectivity, and sensitivity
Summary
Optical probes based on luminescent nanomaterials have drawn considerable attention due to their rapidity, sensitivity, low cost and accuracy for screening of contaminants.[1,2,3] In particular, many uorescent nanomaterials have been applied for fabrication of uorescent probes. Considering the high side effects and urgent requirement of accurate quantitative analysis of TC, it is still necessary to develop a quick and simple method for the determination of TC.[26,27,28] Fabrication of uorescent probes based on SQDs is an ideal candidate for determination of TC with high sensitivity, selectivity and accuracy. The SQDs based uorescent probe shows huge potentials in rapid, selective and sensitive determination of contaminates in food samples
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