Abstract
Surface-enhanced Raman spectroscopy (SERS) is a promising analytical tool due to its label-free detection ability and superior sensitivity, which enable the detection of single molecules. Since its sensitivity is highly dependent on localized surface plasmon resonance, various methods have been applied for electric field-enhanced metal nanostructures. Despite the intensive research on practical applications of SERS, fabricating a sensitive and reproducible SERS sensor using a simple and low-cost process remains a challenge. Here, we report a simple strategy to produce a large-scale gold nanoparticle array based on laser interference lithography and the electrophoretic deposition of gold nanoparticles, generated through a pulsed laser ablation in liquid process. The fabricated gold nanoparticle array produced a sensitive, reproducible SERS signal, which allowed Rhodamine 6G to be detected at a concentration as low as 10−8 M, with an enhancement factor of 1.25 × 105. This advantageous fabrication strategy is expected to enable practical SERS applications.
Highlights
Surface-enhanced Raman spectroscopy (SERS) has attracted a significant amount of attention in chemical [1,2] and biological [3,4,5] analyses because it can detect a molecule’s specific fingerprint with high sensitivity, which enables the detection of even a single molecule [6]
After the electrophoretic deposition (EPD) of the Au NP solution, we found that the Au NPs were well-deposited on the PR template
From the relative standard deviations (RSD) within 10%, we found that a reproducible SERS substrate had been fabricated
Summary
Surface-enhanced Raman spectroscopy (SERS) has attracted a significant amount of attention in chemical [1,2] and biological [3,4,5] analyses because it can detect a molecule’s specific fingerprint with high sensitivity, which enables the detection of even a single molecule [6]. In addition to the different sizes [8] and shapes [9,10,11] of metal nanoparticles (NPs), self-assembly [12], electroless deposition [13], and other strategies [14,15,16] have been reported. These methods are highly sensitive, simple, and inexpensive, but they often have low reproducibility owing to the randomly deposited NPs [17]
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