Abstract

 
 
 
 Purpose: To develop simple, rapid, and selective spectrophotometric methods for the assay of sertraline in a pharmaceutical formulation.
 Method: These methods depend on the formation of colored ion-pair complexes between the drug and five different reagents; methyl blue (MB), bromophenol red (BPR), methyl green (MG), phenol red (PR), and methyl orange (MO) in B-R buffer solutions of pH ranging from 2.0 – 8.0. The colored products were measured at 668, 747, 647, 717, and 553 nm, respectively.
 Results: The calibration graphs were linear over the concentration range of 2 – 18 μg/mL for MB and BPR, and 2 – 16 μg/mL for MG, PR, and MO. In all cases, the reaction stoichiometry was 1:1. The proposed methods were successfully applied to solid-dose pharmaceutical preparations (tablets). Excipients in the commercial formulation did not interfere with the analysis.
 Conclusion: The investigated methods can be recommended for routine analysis and quality control where cost-effectiveness, high specificity of the analytical technique, and time are of great importance.
 
 
 
Highlights
Depression is one of the most common mental diseases in the world which has significantly negative effects on the whole life of patient and may resulted in self-injury and suicide [1]
It has been reported that the daily oral doses of sertraline is in the range of 50 - 200 mg and its steady state plasma concentration is from 55 - 250 ng/mL [2]
The ion-pair spectrophotometry has received a considerable attention for quantitative analysis of many pharmaceutical compounds [19]
Summary
Depression is one of the most common mental diseases in the world which has significantly negative effects on the whole life of patient and may resulted in self-injury and suicide [1]. The selective serotonin reuptake inhibitors (SSRIs) such as sertraline and fluoxetine have become one of the most frequently prescribed drugs for depression treatment [2]. These drugs have many toxic side effect including gastrointestinal disturbance [3]. The level of sertraline in saliva and human milk was found to range between 5 to 500 ng/mL, whereas in the case of plasma and serum, values reported were (0.5-1000 ng/ mL) and (2 - 400 ng/mL) respectively [4,5,6,7,8,9].
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