Sensing without tasting: Postingestive effects of sucrose in the brain of sweet-blind mice

Abstract

Event Abstract Back to Event Sensing without tasting: Postingestive effects of sucrose in the brain of sweet-blind mice Albino J. Oliveira-Maia1*, Clara Monteiro1, Virginia Workman2, Vasco Galhardo2, Sidney A. Simon1 and Miguel A. L. Nicolelis1 1 Duke University Medical Center, Department of Neurobiology, United States 2 Universidade do Porto, Faculdade de Medicina and IBMC, Portugal Food palatability and hedonic value play central roles in nutrient intake. While postingestive effects also have robust influences on food preferences, the neurobiological bases of such influences remain poorly understood. We have previously shown that Trpm5-/- mice, that lack the cellular machinery required for sweet taste transduction, can develop a robust preference for sucrose solutions based solely on caloric content. Sucrose intake induced dopamine release in the ventral striatum of these sweet-blind mice, a pattern usually associated with receipt of palatable rewards, and single neurons in the same ventral striatal region also showed increased sensitivity to caloric intake. More recently, we have found that, in the same mice, sucrose consumption modulates neural population responses and induces Fos expression in the dorsal gustatory areas of the insula. Moreover, bilateral lesions to this brain region abolished the development of conditioned preferences for sucrose. Our findings suggest that calorie-rich nutrients can directly influence brain reward and gustatory circuits that control food intake, independently of palatability or functional taste transduction. Conference: 11th Meeting of the Portuguese Society for Neuroscience, Braga, Portugal, 4 Jun - 6 Jun, 2009. Presentation Type: Oral Presentation Topic: Symposium 2 – Brain Networks Citation: Oliveira-Maia AJ, Monteiro C, Workman V, Galhardo V, Simon SA and Nicolelis M (2009). Sensing without tasting: Postingestive effects of sucrose in the brain of sweet-blind mice. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.013 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Aug 2009; Published Online: 05 Aug 2009. * Correspondence: Albino J Oliveira-Maia, Duke University Medical Center, Department of Neurobiology, Durham, United States, albino.maia@neuro.fchampalimaud.org Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Albino J Oliveira-Maia Clara Monteiro Virginia Workman Vasco Galhardo Sidney A Simon Miguel A. L. Nicolelis Google Albino J Oliveira-Maia Clara Monteiro Virginia Workman Vasco Galhardo Sidney A Simon Miguel A. L. Nicolelis Google Scholar Albino J Oliveira-Maia Clara Monteiro Virginia Workman Vasco Galhardo Sidney A Simon Miguel A. L. Nicolelis PubMed Albino J Oliveira-Maia Clara Monteiro Virginia Workman Vasco Galhardo Sidney A Simon Miguel A. L. Nicolelis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.