Abstract

In this chapter we will discuss some of the most promising label-free technologies with significant impact on the field of biosensing and diagnostics, namely, conventional surface plasmon resonance (SPR), localized surface plasmon resonance (LSPR) and nanostructure SPR arrays. Development of SPR biosensing technology is focused on improving sensitivity, miniaturizing the sensor system, tuning the operation range and high throughput detection [5]. We will discuss plasmonic-based biosensors and their integration with microfluidic chip. The application of SPR sensing platforms integrated with microfluidic chips for detection of nucleic acid and cells will be described in detail. Lastly, we will describe the current state of the art of plasmonic biosensors and give a perspective on the future of this technology for POC diagnostics.

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