Abstract
(Dated: 2nd February 2008)Based on modern single molecule techniques, we devise a number of possible experimental setupsto probe local properties of DNA such as the presence of DNA-knots, loops or folds, or to obtaininformation on the DNA-sequence. Similarly, DNA may be used as a local sensor. Employingsingle molecule fluorescence methods, we propose to make use of the physics of DNA denaturationnanoregions to find out about the solvent conditions such as ionic strength, presence of bindingproteins, etc. By measuring dynamical quantities in particular, rather sensitive nanoprobes may beconstructed with contemporary instruments.Key words: DNA, DNA breathing, single molecule spectroscopy, nanosensors, fluorescence correla-tion spectroscopy, fluorescent resonance energy transfer
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