Sensation, movement and learning in the absence of barrel cortex.

Abstract

For many of our senses, the role of the cerebral cortex in detecting stimuli is controversial1–17. Here, we examine the effects of both acute and chronic inactivation of primary somatosensory cortex (S1) in mice trained to move their large facial whiskers to detect an object via touch and respond with a lever to obtain a water reward. Using transgenic animals, we expressed inhibitory opsins in excitatory cortical neurons. Transient optogenetic inactivation of S1, as well as permanent lesions, initially produced both movement and sensory deficits that impaired detection behavior, demonstrating the inextricable link between sensory and motor systems during active sensing. Surprisingly, lesioned mice rapidly recovered full behavioral capabilities by the subsequent session. Recovery was experience-dependent, and early re-exposure to the task after lesion facilitated recovery. Furthermore, primary sensory cortex ablation prior to learning did not affect task acquisition. This combined optogenetic and lesion approach suggests that manipulations of sensory cortex may be only temporarily disruptive to other brain structures, which are themselves capable of coordinating multiple, arbitrary movements with sensation. Thus, the somatosensory cortex may be dispensable for active detection of objects in the environment.