Abstract
Summary: SensA is a web-based application for sensitivity analysis of mathematical models. The sensitivity analysis is based on metabolic control analysis, computing the local, global and time-dependent properties of model components. Interactive visualization facilitates interpretation of usually complex results. SensA can contribute to the analysis, adjustment and understanding of mathematical models for dynamic systems.Availability and implementation: SensA is available at http://gofid.biologie.hu-berlin.de/ and can be used with any modern browser. The source code can be found at https://bitbucket.org/floettma/sensa/ (MIT license)Contact: max.floettmann@biologie.hu-berlin.de or thomas.spiesser@biologie.hu-berlin.de
Highlights
The understanding of complex systems and their dynamics has greatly improved with mathematical modelling
The sensitivity analysis is based on metabolic control analysis, computing the local, global and time-dependent properties of model components
SensA can contribute to the analysis, adjustment and understanding of mathematical models for dynamic systems
Summary
The understanding of complex systems and their dynamics has greatly improved with mathematical modelling. Sensitivity analysis measures the change of a specific system property (e.g. a steady state concentration, reaction flux or the amplitude of oscillations) in response to changes in parameter values. It shows how sensitive the system is towards a particular parameter. To assess the effect of a perturbation of a parameter or reaction rate on the steady state fluxes or concentrations, we compute global response and control coefficients. A clear focus on sensitivities and a modern Javascript-based front-end make the tool easy to use It extends sensitivity analysis as compared with standard modelling software [e.g. Copasi (Hoops et al, 2006) or JWS online (Olivier and Snoep, 2004)] to include time-dependent sensitivities as well. SensA offers the most complete set of sensitivity analysis we know of
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