SENOLYTIC ACTIVITY EVALUATION OF CORIANDER (Coriandrum sativum L) PHYTOCONSTITUENTS: In-silico STUDY

Abstract

Coriander phytoconstituent has pro-apoptotic and anti-inflammatory activities. This study evaluated the activity of Coriander phytoconstituent against the Senescent Cell Anti-Apoptotic Pathways (SCAPs) network nodes that serve as targets for senolytic drugs. Docking simulations were performed using Autodock Vina PyRx (v0.8), Autodock Tools 1.5.6, and visualized by the Discovery Studio Visualizer. The anti-apoptotic protein (BCL-XL, BCL-2, BCLW, and survivin) interaction network was obtained from String db.org. The flavonoid compounds showed good binding energy than non-flavonoid compounds. In flavonoid compounds, referring to the binding energy of standard drugs, rutin have a potent affinity to survivin with a binding energy of -7.47 kcal/mol. In addition, the binding energy of galangin-5-methylether, pectolinarigenin, luteolin, apigenin, and 5,6,7-trimethoxyflavone serve higher binding activity to BCL-XL in the ranges -7.73 – -8.64 kcal/mol. Meanwhile, pseudobaptigenin has an affinity to both proteins, survivin, and BCL-XL with the binding energy of -5.71 and -8.64 kcal/mol respectively. Hence, the coriander phytoconstituents could have the potential as a senolytic agent by interfering with the SCAPs, especially BCL-XL and survivin