Senescent Stromal Fibroblasts Secrete MMP-2 Which Promotes The Invasion of OSCC Keratinocyte Cells

Abstract

regulation of a broad spectrum of cell-cell adhesion molecules including Desmoglein 1 and 3, Desmoplakin, b-catenin, Plakophilin and Desmocolin. The induction of EMT and down-regulation of adhesion molecules was associated with a less cohesive and more invasive epithelial phenotype. Inhibition of CAFderived TGF-b reduced the ability of senescent fibroblasts to promote keratinocyte tumour cell dissociation and invasion in vitro. Conclusions: Senescent stromal fibroblasts promote tumour cell invasion by the downregulation of cell-cell adhesion molecules and the induction of keratinocyte discohesion, a heterotypic cell interaction that occurs in a TGF-b dependent manner.