Abstract
Virus infection of cell cultures induces the synthesis of various cytokines which can either inhibit or stimulate virus replication. The Sendai virus induces large quantities of biologically active interferon (IFN-αn3) in human peripheral blood leukocytes (hPBL) in vitro, as well as many other cytokines. The supernatants of Sendai virus-infected hPBL contained biologically active IFN-αn3, significant amounts of immunogenic IFN-γ, monokines (IL-1α, IL-β, TNF-α), lymphokines (IL-6, TNF-β), growth factor (PDGF-AB) and small concentrations of IL-2 and GM-CSF. The analysis of the influence of the Sendai virus inactivation by lowering pH 2.0 on the cytokine concentrations showed that IL-1α, TNF-α, TNF-β and IFN-γ are susceptible to acid conditions, while IFN-αn3, IL-1β, IL-6 and IL-2 concentrations remained unchanged.
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