Semisynthetic cephalosporines. The synthesis of some substituted tetrazolylacetic acids

Abstract

5-[5-(Substituted phenyl)-2-furyl]-1-tetrazolylacetic acids were synthesized from ethyl 5-(substituted phenyl)-2-furylcarbamidoacetates and phosphorus pentachloride via the corresponding imidoyl chlorides, which gave with sodium azide the respective ethyl 5-[5-(substituted phenyl)-2-furyl]-1-tetrazolyl acetates. A positive antiinflammatory effect was found when testing the acids obtained by hydrolysis of the acetates prepared.