Abstract
The application of the Lemieux-Nagabhushan reaction to the synthesis of antibiotic JI-20A and gentamicin B from a suitably protected garamine derivative is described. 3′-Deoxy-6′-N-methyl analogues of antibiotic JI-20A and gentamicin B have also been prepared from garamine intermediates. The transformation of 3′-deoxygentamicin X2 into the 6′-deoxy-6′-methylamino-derivative is discussed.
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