Abstract
This seminar has been concerned with the presentation of a rationale for the existence of tumor specific substances and an immune response in cancer.The importance of the inbred animal and an isogenic tumor-host relationship has been stressed.Experiments showing that a tumor-resistant state can be induced in such an isologous system have also been presented.Certain natural heterohemagglutinins present in normal rat serum and involved in a “negative phase” following tumor implantation, have been used to serologically characterize an ethanol extractable substance common to both normal and malignant rat tissues, and a substance which appears to be peculiar to the several rat neoplasia studied.
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