Seminal Vesicle Biopsy in Prostate Cancer Staging

Abstract

Purpose Prostate cancer patients were differentiated using seminal vesicle biopsies related to clinical staging, prostate specific antigen (PSA), Gleason scores and PSA density values. Materials and Methods A total of 75 patients underwent seminal vesicle biopsies. Patients with no seminal vesicle invasion and negative lymphadenectomy results underwent radical prostatectomy. Results Efficacy of seminal vesicle biopsy was 90.9 percent. Infiltration rates were 69 percent for disease stage T2b or greater, 68 percent for PSA greater than 10 ng./ml., 78 percent for PSA greater than 20 ng./ml. and 73 percent for type 4 and/or 5 Gleason scores. For the prognosis of seminal vesicle invasion, 0.40 was the best PSA density cutoff point. Conclusions We recommend seminal vesicle biopsy in patients with stage T2b or greater disease, and with a lower clinical stage when the PSA level is 20 ng./ml. or greater and/or the Gleason score is 7 or greater.