Abstract

There is a growing body of evidence that diabetic conditions are associated with sexual problems. Metabolism of trace elements is altered in diabetic mellitus, and they may have a specific role in the pathogenesis and progression of the disease. The aims of this study are to investigate the levels of zinc and magnesium in semen of patients with diabetes mellitus and to find out if there is any association between trace elements and semen parameters in these diabetic subjects. Semen samples from 25 diabetic men and 25 nondiabetic were analyzed for physical and biochemical parameters. Zinc (Zn) and magnesium (Mg) levels were estimated by atomic absorption spectrophotometry. Zn and Mg concentrations in seminal plasma of nondiabetic men were more elevated than in diabetic groups. Zn showed positive and significant correlations with sperm motility (p < 0.05, r = 0.52) and morphology (p < 0.05, r = 0.44). Mg was significantly correlated with sperm motility (p < 0.05, r = 0.51) and morphology (p < 0.05, r = 0.48). Seminal plasma Zn and Mg showed a negative correlation with HbA1c, which was statistically significant (r = −0.380 and r = −0.367, p < 0.05). Zn and Mg deficiencies become visible as an additional risk factor in the development of diabetes, and they are involved in the pathogenesis of diabetes mellitus and its complications. Adequate administration of these elements may be an effective therapeutic intervention in the prevention of the progression of the diabetes and its complications, along with a glycemic control and control of other risk factors.

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