Abstract
Seminal plasma allergy (SPA) is an immunological reaction against human seminal plasma observed in women. SPA is not a well‐known clinical syndrome, considering that there are few epidemiological studies on SPA, and it can often be overlooked or misdiagnosed as other medical conditions. Symptoms occur after sexual intercourse and manifest as systemic and/or localized symptoms. The pathophysiology of SPA is commonly assumed to be autoimmune reaction to seminal plasma with IgE antibodies ; however, it is still uncertain which specific antibodies cause SPA. In vivo skin tests, including prick and intradermal tests, are useful for diagnosing SPA. However, there has been no consensus on treatment of SPA, apart from symptomatic therapy, although several desensitization methods have been reported, using emergency kits for allergic reactions. The most common and most effective preventive measure for SPA is to use condoms during intercourse.
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