Seminal oxidative stress (OS) is highly correlated with sperm DNA damage in men with idiopathic and male-factor infertility

Abstract

SPERM DNA DAMAGE IN MEN WITH IDIOPATHIC AND MALEFACTOR INFERTILITY Ramadan A Saleh, Ashok Agarwal, Cleveland Clinic Foundation, Essam A Nada, South Valley University, Mohamed H El-Tonsy, al-Minya University, Donald P Evenson, Kjersten Larson, South Dakota State University Objective: Seminal OS is due to an imbalance between reactive oxygen species (ROS) and total antioxidant capacity (TAC) in semen and is involved in many aspects of male infertility. Our group has recently introduced the composite ROS-TAC score as an accurate measure of seminal OS. In this study, we examined the correlation of seminal OS with sperm DNA damage and standard sperm parameters in infertile men with idiopathic and malefactor infertility.