Seminal Anti-Mullerian Hormone in Fertile and Infertile Men = هورمون إنتي-موليرين المنوي في الرجال الخصيبين و العقيمين

Abstract

Objective: Anti-Mullerian hormone (AMH) is a glycoprotein of the transforming growth factor β-superfamily, is produced by Sertoli cells and have been proposed as direct marker of their function and indirect marker of spermatogenesis. The aim of this study is to demonstrate that serum and seminal AMH as non-invasive marker of spermatogenesis in infertile men and to find the relationship between seminal AMH, FSH, LH, prolactin and testosterone. The aim of this study is to demonstrate that serum and seminal AMH as non-invasive marker of spermatogenesis in infertile men and to find the relationship between seminal AMH, FSH, LH, prolactin and testosterone. Setting: Al-Batool Teaching Hospital and Al-Duaa clinical lab. Design : prospective study. Participants and Methods: The study was conducted on seventy male subjects aged less than fifty years for the period from Sept2012-Feb2013. Infertile men were classified into azoospermics (n=20), oligospermics (n=20), and fertile men as controls (n=30). Serum concentrations of FSH, LH, prolactin and testosterone were measured using ELISA. Serum AMH and AMH in seminal plasma concentrations were measured using AMH/MIS enzyme immunoassay sorbant kit. Results: Infertile men had lower seminal and serum AMH levels and was statistically significant. There was a significant negative correlation between seminal AMH and FSH in azoospermic men while no significant correlation was found with LH, prolactin and testosterone. Concerning oligospermic men, a significant positive correlation was found between seminal AMH and testosterone while no significant correlation was found with FSH, LH and prolactin. Conclusion: the present study found that AMH in seminal plasma can be used as indirect marker of infertility in men.