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Abstract
Semiconductor quantum dots (QDs) or nanoparticles (NPs) exhibit very unusual physico-chemcial and optical properties. This review article introduces the applications of semiconductor nanomaterials (NMs) in fluorescence spectroscopy and matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) for biomolecule analysis. Due to their unique physico-chemical and optical properties, semiconductors NMs have created many new platforms for investigating biomolecular structures and information in modern biology. These semiconductor NMs served as effective fluorescent probes for sensing proteins and cells and acted as affinity or concentrating probes for enriching peptides, proteins and bacteria proteins prior to MALDI-MS analysis.
Highlights
Nanomaterials have been integrated in various analytical tools to gain prominence advances in bioanalytical and proteomics research communities since last decade
It is noticed that effective masses of charge carriers in semiconductors are less than the free electron mass, so that quantum confinement energy is observed at room temperature comparatively at a larger size in contrast to the case of a metal, where quantum confinement energy can be observed at a low temperature only for a cluster of few atoms
We described the dual application of 12-hydroxy octadecanoic acid (HOA)-modified barium titanate nanoparticles (BaTiO3 NPs) in MALDI-MS for the analysis of phospholipids (PLs; L-A-phosphatidyl-l-serine (PS) and L-A-phsophatidic acid sodium (PA)) and hydrophobic proteins in E. coli [119]
Summary
Nanomaterials have been integrated in various analytical tools to gain prominence advances in bioanalytical and proteomics research communities since last decade. Different sizes of QDs can be excited simultaneously by a single wavelength and emit with distinctly different colors. In this connection, the swift progress of this field of research has been well addressed in monographs and review articles dealing with the synthesis, physico-chemical, optical properties and applications of QDs [10,11,12]. The swift progress of this field of research has been well addressed in monographs and review articles dealing with the synthesis, physico-chemical, optical properties and applications of QDs [10,11,12] These reports reveal that the semiconductor nanomaterials are attractive and have interesting structures for proteome analysis with high sensitivity. We briefly introduced on semiconductor nanomaterials and their uses as the optical probes in fluorescence spectroscopy and as affinity probes in MALDI-MS for proteome analysis
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