Abstract
Stepwise multiple regression affirmed that cAFP and cBIL contributed to the variation in the peak serum bilirubin concentration, r = 0.504, P <0.0001. In this study they were the only cord blood substances found to associate with postnatal serum bilirubin concentrations. However, no significant correlation existed between them. The incidence of idiopathic NNJ in a local Chinese population reported in 1986 was 23.8% [3]. Assuming the same incidence today, the positive predictive value and the efficiency of using a combination of cAFP (at a cutoff concentration of 100 000 j.tg/L) and cBIL (at a cutoff concentration of 29 j.molIL) would be 52.3% and 77.7%, respectively. We conclude that a combination of cAFP and cBIL can be used as a predictive marker for the development of idiopathic NNJ. Our results also indicated that both liver immaturity and increased bilirubin production were associated with the development of hyperbilirubinemia in newborn infants.
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