Abstract
Autosomal dominant polycystic kidney disease (ADPKD) eventually leads to end stage renal disease (ESRD) with an increase in size and number of cysts over time. Progression to ESRD has previously been shown to correlate with total kidney volume (TKV). An accurate and relatively simple method to perform measurement of TKV has been difficult to develop. We propose a semi-automated approach of calculating TKV inclusive of all cysts in ADPKD patients based on b0 images relatively quickly without requiring any calculations or additional MRI time. Our purpose is to evaluate the reliability and reproducibility of our method by raters of various training levels within the environment of an advanced 3D viewer. Thirty patients were retrospectively identified who had DWI performed as part of 1.5T MRI renal examination. Right and left TKVs were calculated by five radiologists of various training levels. Interrater reliability (IRR) was estimated by computing the intraclass correlation (ICC) for all raters. ICC values calculated for TKV measurements between the five raters were 0.989 (95% CI = (0.981, 0.994), p < 0.01) for the right and 0.961 (95% CI = (0.936, 0.979), p < 0.01) for the left. Our method shows excellent intraclass correlation between raters, allowing for excellent interrater reliability.
Highlights
Rising healthcare expenditures—both on a personal [1] and national level [2,3]—are no surprise to anyone
We propose a semi-automated approach of total kidney volume (TKV) calculation based on b0 images, which allow for the greatest contrast between the hyperintense kidneys and cysts and the remainder of the visualized adjacent intraabdominal structures
We presented a novel method of calculating TKVs in patients with autosomal dominant polycystic kidney disease (ADPKD), which we believe offers several advantages compared to prior methods
Summary
Rising healthcare expenditures—both on a personal [1] and national level [2,3]—are no surprise to anyone. We propose a semi-automated approach of TKV calculation based on b0 images, which allow for the greatest contrast between the hyperintense kidneys and cysts and the remainder of the visualized adjacent intraabdominal structures This sequence is already routinely performed as part of our renal mass protocol MRI abdomen, and no additional sequences or time would need to be added to the exam time. Our purpose in this study is to evaluate the reliability and reproducibility of calculating TKVs, inclusive of all renal cysts, in ADPKD patients, using our semi-automated b0 method This will be performed by raters of various training levels within the environment of an advanced 3D viewer
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