Semen quality improves marginally during young adulthood: a longitudinal follow-up study

Abstract

STUDY QUESTIONDoes semen quality improve during early adulthood?SUMMARY ANSWERSemen variables change little during the third decade of life, however some improvement in sperm morphology and motility may occur.WHAT IS KNOWN ALREADYA suspicion of deteriorating semen quality has been raised in several studies. The longitudinal development of semen quality in early adulthood is insufficiently understood.STUDY DESIGN, SIZE, DURATIONA longitudinal follow-up of two cohorts of volunteer young adult Finnish men representing the general population was carried out. Cohorts A (discovery cohort, born 1979–1981, n = 336) and B (validation cohort, born 1983, n = 197) were followed up from the age of 19 years onward for 10 years.PARTICIPANTS/MATERIALS, SETTING, METHODSInclusion criteria included that both the men and their mothers were born in Finland. Semen analysis was performed in cohorts A and B at 2–4 year intervals over a period of 10 years. Semen volume, sperm concentration, total sperm count, motility, total motile count and morphology were the variables assessed in the analysis. A physical examination was carried out at each visit to detect any significant andrological abnormalities. The overall participation rate was 13.4%.MAIN RESULTS AND THE ROLE OF CHANCEDuring the follow-up, the percentage of sperm with normal morphology and the percentage of motile sperm increased significantly both in the discovery (A) (P < 0.001 at 19 versus 29 years for both) and validation (B) (P < 0.001 and P = 0.03 at 19 versus 29 years, respectively) cohort. Sperm concentration and total sperm count showed a significant increase with age only in cohort B (P = 0.03 at 21 versus 29 years, P = 0.009 at 19 versus 29 years, respectively).LIMITATIONS, REASONS FOR CAUTIONA limited number of men participated both in the first round and in the final fourth round (cohort A, n = 111 and cohort B, n = 90 men) and in all four rounds (cohort A, n = 61 and cohort B, n = 52).WIDER IMPLICATIONS OF THE FINDINGSAlmost full spermatogenic capacity is reached by the age of 19 years. However, the improvement in sperm motility and morphology during early adulthood may slightly improve male fecundity.STUDY FUNDING/COMPETING INTEREST(S)This study was supported by the European Commission (QLK4-CT-1999-01422, QLK4-CT-2001-00269, QLK4-2002-0063, FP7/2008-2012: DEER 212844), The Danish Medical Research Council (9700833, 9700909), Danish Agency for Science (Technology and Innovation 09-067180), the Svend Andersen's Foundation, Velux Foundation, and Novo Nordisk Foundation, the Turku University Hospital, Sigrid Jusélius Foundation and the Academy of Finland. There are no conflicts of interest.