Abstract
Cancer Tumors of patients with metastatic pancreatic ductal adenocarcinoma (PDAC) contain elevated levels of semaphorin 3D, which guides the growth of new blood vessels. Foley et al. found that the protein annexin A2 increased the release of semaphorin from tumor cells from a genetic mouse model of PDAC and promoted migration in these cells. Knockdown of annexin A2 in PDAC cells decreased the ability of these cells to colonize the liver and lungs when injected into mice. These prometastatic effects of annexin A2 did not involve changes in tumor vascularization. Sci. Signal. 8 , ra77 (2015).
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