Abstract

Dementia is a neurodegenerative disease that leads to the development of cognitive deficits, such as aphasia, apraxia, and agnosia. It is currently considered one of the most significant major medical problems worldwide, primarily affecting the elderly. This condition gradually impairs the patient’s cognition, eventually leading to the inability to perform everyday tasks without assistance. Since dementia is an incurable disease, early detection plays an important role in delaying its progression. Because of this, tools and methods have been developed to help accurately diagnose patients in their early stages. State-of-the-art methods have shown that the use of syntactic-type linguistic features provides a sensitive and noninvasive tool for detecting dementia in its early stages. However, these methods lack relevant semantic information. In this work, we propose a novel methodology, based on the semantic features approach, by using sentence embeddings computed by Siamese BERT networks (SBERT), along with support vector machine (SVM), K-nearest neighbors (KNN), random forest, and an artificial neural network (ANN) as classifiers. Our methodology extracted 17 features that provide demographic, lexical, syntactic, and semantic information from 550 oral production samples of elderly controls and people with Alzheimer’s disease, provided by the DementiaBank Pitt Corpus database. To quantify the relevance of the extracted features for the dementia classification task, we calculated the mutual information score, which demonstrates a dependence between our features and the MMSE score. The experimental classification performance metrics, such as the accuracy, precision, recall, and F1 score (77, 80, 80, and 80%, respectively), validate that our methodology performs better than syntax-based methods and the BERT approach when only the linguistic features are used.

Highlights

  • Dementia, defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM 5) [1] as a major neurocognitive disorder, is a condition with etiological subtypes in which different levels of dysfunction are recognized

  • The metrics mentioned above are defined in terms of the correctly estimated values, namely, the true positives (TP) and true negatives (TN), as well as the incorrect predictions, namely, the false positives (FP) and false negatives (FN) [52]

  • We argue that a basic model for the denomination of dementia could be deprecated on the Mini-Mental State Examination (MMSE) score if the lexical, syntactic, semantic, and demographic features are used

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Summary

Introduction

Dementia, defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM 5) [1] as a major neurocognitive disorder, is a condition with etiological subtypes in which different levels of dysfunction are recognized It affects older adults, showing its first signs at the age of 60 years old. The characteristic symptoms of AD are linguistic deficits in oral and written expression, difficulty in motor planning, and impaired sensory and spatial perception [1]. This is reflected in the aspects of the intellectual functions and processes, such as attention, memory, cognition, decision making, planning, reasoning, judgment, perceptual comprehension, language, and the visuospatial function [3]. The standard diagnostic procedure corroborates deficits in two or more cognitive areas with neuropsychological tests and physical and neurological examinations

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