Semantic categorisation of novel objects in frontotemporal dementia

Abstract

Impaired semantic memory is ubiquitous in frontotemporal dementia (FTD), including patients with semantic dementia (SD), progressive nonfluent aphasia (PNFA) and nonaphasic FTD patients with a deficit in executive and social functioning (EXEC/SOC). One hypothesis attributes this to the degradation of specific categories of knowledge in semantic memory. This study explores the alternate hypothesis that impaired semantic memory in FTD can also reflect limitations in the categorisation processes that determine object meaning. Patients were taught a novel semantic category under two conditions: rule-based categorisation, where executive resources support the evaluation of specific features to determine category membership; and similarity-based categorisation, where category membership is determined by the overall resemblance of an item to a prototype or recalled exemplars. In the first experiment, patients learned a novel category composed of highly salient features. For SD patients, we found category membership judgment profiles following rule-based and similarity-based training that resembled the performance of control subjects. Categorisation was impaired following rule-based training in PNFA and EXEC/SOC patients. In the second experiment, we modified the category so that membership was determined by less salient features, thus increasing the burden on executive resources. Under these circumstances, SD patients' categorisation profiles continued to resemble those of control subjects, PNFA patients' category judgments were governed by feature salience, and EXEC/SOC patients' judgments were limited by impaired executive resources. These observations suggest that the semantic memory deficit in SD largely reflects degraded feature knowledge for familiar objects, while impaired semantic memory in PNFA and in EXEC/SOC patients largely reflects a deficit in the processes associated with semantic categorisation. Portions of this work were presented at the Fourth International Meeting of Frontotemporal Dementia in Lund, Sweden, April 2003.