Abstract
The aim of the present study is to develop and optimize self-nanoemulsifying drug delivery systems (SNEDDS) to improve the stability and solubility of dihydromyricetin (DHM). Solubility of DHM was tested in various vehicles to select proper combinations of components; ternary phase diagrams were constructed to investigate the proportion of formula of emulsion. Based on the results of emulsification grade and thermodynamic stability, the DHM-SNEDDS was formed by using medium chain triglycerol (MCT) as oil phase; Cremophor-RH40 as surfactant; and glycerol as co-surfactant. The particle size distribution, zeta potential, and polydispersity index were analyzed to be 56.54 ± 0.36 nm, −5.21 ± 0.54 mV and 0.312 ± 0.08, respectively. The maximum observed drug loading was 45 mg/kg, the obtained loading efficiency was extremely good. The in vitro release profile of DHM-SNEDDS was found significant in comparison to the plain DHM suspension. Hence, SNEDDS could be a promising strategy to overcome the poor water solubility and short biological half-life of DHM for further application in functional foods and beverage industry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
